Sperm DNA integrity testing—a valuable clinical tool

Sperm DNA integrity testing—a valuable clinical tool

For long, spermatozoa were only considered as vectors carrying the paternal genetic material to the oocyte. However, over the recent years, the important contribution of the spermatozoa to embryogenesis has become better understood. It is now evident that sperm cells are highly differentiated, polarized and specialized, containing the paternal constituents required for fertilization and normal ...

Sperm DNA integrity testing: a valuable addition to the tool box of infertility clinicians

The clinical utility of sperm DNA integrity testing.

Sperm DNA damage is more common in infertile men and may contribute to poor reproductive performance. However, current methods for evaluating sperm DNA integrity do not reliably predict treatment outcomes, and no treatment for abnormal DNA integrity has proven clinical value.

P-19: Effect of Three Sperm Preparation Methods on Sperm DNA Integrity and Oocyte Fertilization Rate

Background: Techniques of sperm preparation require centrifugation to separate spermatozoa from the seminal plasma. The centrifugation can induce damage to the spermatozoa and increase reactive oxygen species(ROS) productionspecially in leukospermic speciemens that are associated with impaired function and fertilizing capacity. However in ICSI, fertilization can occure with damage DNA sperm but...

Sperm DNA integrity: from ‘promising’ to standardization

tau.amegroups.com © Translational Andrology and Urology. All rights reserved. Human assisted reproduction results have improved dramatically in the last 20 years, with lower complications for the patient as well as for the newborns. This requires a precise clinical diagnosis that will allow us to individualize the best-personalized treatment for each patient or couple. But still today, the basi...